Research Associate

35 333 £
Date Placed 11 January

The role

A Wellcome Trust-funded post-doctoral position in Protein Biochemistry is available from 1st March 2023 in the Schaffitzel team at the School of Biochemistry, University of Bristol and at the cutting-edge Bristol Engineering Biology Centre, BrisEngBio, a leading UK and international centre of excellence.

What will you be doing?

As part of a dynamic interdisciplinary team, you will analyse the functional interactions of factors involved in nonsense-mediated mRNA decay in vitro and in vivo. You will reconstitute relevant complexes of the factors with interaction partners including ribosomes and mRNA and characterise these using biochemical, biophysical and structural biology techniques, in particular cryo-EM.

You will be based in the Schaffitzel (lead) team and work in a highly collaborative setup including the Berger group (Bristol), the Kulozik and Hentze groups (Univ. of Heidelberg, Germany) and Rappsilber group (Univ. of Edinburgh & Berlin).

You should apply if

You should apply if you have experience with molecular biology techniques, protein expression and protein purification techniques. All working experience with biochemical, biophysical and structural analyses techniques, in particular cryogenic electron microscopy, is a big plus.

You have a keen interest in scientific questions under investigation in the lab coupled with enthusiasm, ambition and strong work ethic. You have a published track record of research productivity in leading life science journals (published or in press / in revision) at a level that is appropriate for your current career stage.

You should be willing to travel occasionally and have flexible working practice.

Additional information

For informal enquiries please contact Christiane Berger-Schaffitzel via email:

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Click here to apply online